Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537696 | 1.00 | MEN1 (0.53) | MEN1KMT2ASNCACYP3A4MAPT | |
| SCHEMBL23537814 | 0.86 | MAPK1 (0.53) | MAPTL3MBTL1NNMT | |
| SCHEMBL7530322 | 0.84 | MAPT (0.63) | MEN1KMT2AMAPTALDH1A1TSHR | |
| SCHEMBL8055864 | 0.83 | MEN1 (0.54) | MEN1KMT2ASNCACYP3A4MAPT | |
| SCHEMBL1461229 | 0.83 | MEN1 (0.54) | MEN1KMT2ASNCACYP3A4MAPT | |
| SCHEMBL13563235 | 0.81 | MEN1 (0.53) | MEN1KMT2ASNCACYP3A4MAPT | |
| SCHEMBL10664482 | 0.81 | KMT2A (0.53) | MEN1KMT2ASNCACYP3A4MAPT | |
| SCHEMBL2661626 | 0.81 | MEN1 (0.53) | MEN1KMT2ASNCACYP3A4ALDH1A1 | |
| SCHEMBL8050188 | 0.80 | MAPK1 (0.58) | MEN1KMT2ASNCACYP3A4L3MBTL1 | |
| SCHEMBL175786 | 0.79 | SNCA (0.67) | MEN1KMT2ASNCACYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077306-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |