Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 17/20 | 0.40 |
| ▸ | PRF1 | P14222 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286208 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL30444525 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL30444657 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL2891319 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL2899747 | 0.80 | KCNJ1 (0.55) | KCNJ1KCNH2 | |
| SCHEMBL286511 | 0.77 | KCNJ1 (0.43) | KCNJ1 | |
| SCHEMBL286415 | 0.77 | KCNJ1 (0.43) | KCNJ1KCNH2 | |
| SCHEMBL14726343 | 0.77 | KCNJ1 (0.43) | KCNJ1KCNH2 | |
| SCHEMBL3808243 | 0.76 | KCNJ1 (0.43) | KCNJ1PRF1KCNH2 | |
| SCHEMBL286489 | 0.76 | KCNJ1 (0.40) | KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771005-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2014-09-03 | — | — | EP | disclosed |
| EP-2744499-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013062892-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2013028474-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-02-28 | — | — | WO | disclosed |
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129379-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |