Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.65 |
| ▸ | JAK2 | O60674 | 12/20 | 0.65 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20400705 | 1.00 | JAK1 (0.65) | JAK1JAK2TYK2 | |
| SCHEMBL20399935 | 0.92 | JAK2 (0.65) | JAK1JAK2 | |
| SCHEMBL30018533 | 0.92 | JAK2 (0.65) | JAK1JAK2 | |
| SCHEMBL23522368 | 0.91 | JAK1 (0.65) | JAK1JAK2 | |
| SCHEMBL30018516 | 0.86 | JAK1 (0.61) | JAK1JAK2TYK2 | |
| SCHEMBL21751129 | 0.86 | JAK1 (0.61) | JAK1JAK2TYK2 | |
| SCHEMBL21870794 | 0.86 | JAK1 (0.61) | JAK1JAK2TYK2 | |
| SCHEMBL30017095 | 0.83 | JAK2 (0.66) | JAK1JAK2 | |
| SCHEMBL20400007 | 0.83 | JAK2 (0.66) | JAK1JAK2 | |
| SCHEMBL21870726 | 0.81 | JAK2 (0.61) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115925693-B | JAK1 selective inhibitors | 阿斯利康(瑞典)有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-115925693-B | JAK1 selective inhibitors | 阿斯利康(瑞典)有限公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-118580223-A | Xinafoate salts of JAK inhibiting compounds | 阿斯利康(瑞典)有限公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-112424187-B | Xinafoate salts of JAK inhibiting compounds | 阿斯利康(瑞典)有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-117924249-A | Preparation method of JAK1 inhibitor AZD4604 | 云南万宏医药科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-115925693-A | Selective inhibitors of JAK1 | 阿斯利康(瑞典)有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-110461830-B | Selective inhibitors of JAK1 | 阿斯利康(瑞典)有限公司 | 2022-11-01 | — | — | CN | disclosed |