Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537293 | 1.00 | PARP1 (0.43) | PARP1TNKSTNKS2NFKB1NFKB2 | |
| SCHEMBL29824164 | 1.00 | PARP1 (0.43) | PARP1TNKSTNKS2NFKB1NFKB2 | |
| SCHEMBL29824425 | 1.00 | PARP1 (0.43) | PARP1TNKSTNKS2NFKB1NFKB2 | |
| SCHEMBL30023596 | 0.92 | TNKS (0.40) | PARP1TNKSTNKS2NFKB1NFKB2 | |
| SCHEMBL23537227 | 0.92 | TNKS (0.40) | PARP1TNKSTNKS2NFKB1NFKB2 | |
| SCHEMBL29824451 | 0.92 | TNKS (0.40) | PARP1TNKSTNKS2NFKB1NFKB2 | |
| SCHEMBL23537417 | 0.85 | PARP1 (0.41) | PARP1 | |
| SCHEMBL29824412 | 0.85 | PARP1 (0.41) | PARP1 | |
| SCHEMBL23537222 | 0.83 | PARP1 (0.49) | PARP1TNKSTNKS2KDM4EALDH1A1 | |
| SCHEMBL29824229 | 0.83 | PARP1 (0.49) | PARP1TNKSTNKS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076648-A1 | SUBSTITUTED BICYCLIC AND TRICYCLIC UREAS AND AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-10-26 | — | — | EP | disclosed |