Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1576408 | 1.00 | MCL1 (0.61) | MCL1HSD17B10MAPTNPC1MAPK1 | |
| SCHEMBL2076719 | 0.86 | MAPT (0.59) | MCL1HSD17B10MAPTNPC1MAPK1 | |
| SCHEMBL7491758 | 0.86 | MCL1 (0.66) | MCL1HSD17B10FFAR1PPARGPPARD | |
| SCHEMBL12468989 | 0.85 | MAPT (0.56) | MCL1HSD17B10MAPTNPC1MAPK1 | |
| SCHEMBL14683466 | 0.85 | MAPT (0.58) | MCL1HSD17B10MAPTNPC1MAPK1 | |
| SCHEMBL11948007 | 0.85 | MAPT (0.58) | MCL1HSD17B10MAPTNPC1MAPK1 | |
| SCHEMBL29540748 | 0.84 | PTPN7 (0.58) | MCL1HSD17B10MAPTFFAR1PPARG | |
| SCHEMBL5278365 | 0.84 | PTPN7 (0.58) | MCL1HSD17B10MAPTFFAR1PPARG | |
| SCHEMBL29540672 | 0.84 | MCL1 (0.72) | MCL1HSD17B10MAPTPPARDPTPN7 | |
| SCHEMBL118785 | 0.84 | MCL1 (0.72) | MCL1HSD17B10MAPTPPARDPTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112204009-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |