Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 20/20 | 0.64 |
| ▸ | TTK | P33981 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30031038 | 0.93 | PRKDC (0.64) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL23948185 | 0.90 | PRKDC (0.68) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL30030910 | 0.89 | PRKDC (0.64) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL30029816 | 0.88 | PRKDC (0.60) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL30029796 | 0.88 | PRKDC (0.62) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL23948607 | 0.88 | PRKDC (0.70) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL29501980 | 0.88 | PRKDC (0.66) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL30030868 | 0.87 | PRKDC (0.70) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL30029430 | 0.85 | PRKDC (0.70) | PRKDCTTKKCNH2PIK3CDCSF1R | |
| SCHEMBL23948202 | 0.82 | PRKDC (0.84) | PRKDCTTKKCNH2PIK3CDCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022177302-A1 | PYRIMIDINE-FUSED RING COMPOUND WITH DNA-PK INHIBITION ACTIVITY AND USE THEREOF | 보령제약 주식회사 | 2022-08-25 | — | — | WO | claimed |
| WO-2022177302-A1 | PYRIMIDINE-FUSED RING COMPOUND WITH DNA-PK INHIBITION ACTIVITY AND USE THEREOF | 보령제약 주식회사 | 2022-08-25 | — | — | WO | disclosed |