Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.54 |
| ▸ | FLT3 | P36888 | 4/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28905423 | 1.00 | MAP4K1 (0.54) | MAP4K1NTRK1KITFLT3DYRK1A | |
| SCHEMBL20791776 | 0.91 | MAP4K1 (0.51) | MAP4K1NTRK1KITFLT3DYRK1A | |
| SCHEMBL30033440 | 0.90 | CLK2 (0.42) | MAP4K1NTRK1KITFLT3DYRK1A | |
| SCHEMBL28905421 | 0.90 | CLK2 (0.42) | MAP4K1NTRK1KITFLT3DYRK1A | |
| SCHEMBL29746585 | 0.84 | MAP4K1 (0.69) | MAP4K1NTRK1KITFLT3DYRK1A | |
| SCHEMBL19949984 | 0.84 | MAP4K1 (0.69) | MAP4K1NTRK1KITFLT3DYRK1A | |
| SCHEMBL19949764 | 0.80 | MAP4K1 (0.46) | MAP4K1NTRK1KITFLT3 | |
| SCHEMBL24752609 | 0.74 | LRRK2 (0.45) | MAP4K1FLT3DYRK1ACLK2CLK3 | |
| SCHEMBL20791770 | 0.74 | NTRK1 (0.46) | MAP4K1NTRK1KITFLT3LRRK2 | |
| SCHEMBL20791772 | 0.74 | MAP4K1 (0.45) | MAP4K1NTRK1KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433161-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-12-06 | — | — | CN | disclosed |