Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23579569 | 1.00 | NPC1 (0.33) | NPC1RAB9AAXLPRKCI | |
| SCHEMBL30067046 | 0.81 | AXL (0.31) | AXLPRKCI | |
| SCHEMBL30067145 | 0.78 | KDM4E (0.33) | AXLPRKCI | |
| SCHEMBL28999202 | 0.76 | — | — | |
| SCHEMBL1674091 | 0.75 | NPC1 (0.33) | NPC1RAB9A | |
| SCHEMBL11104624 | 0.73 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL24265351 | 0.70 | NPC1 (0.37) | NPC1RAB9A | |
| SCHEMBL9542666 | 0.69 | NPC1 (0.39) | NPC1RAB9A | |
| SCHEMBL28608327 | 0.68 | DYRK1A (0.31) | — | |
| SCHEMBL8684310 | 0.65 | MEN1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151550-B | External nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) modulators and uses thereof | 桑福德·伯纳姆·普雷比医学发现研究所 | 2024-11-22 | — | — | CN | disclosed |
| EP-4081528-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-11-02 | — | — | EP | disclosed |