Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.46 |
| ▸ | KDR | P35968 | 8/20 | 0.45 |
| ▸ | TEK | Q02763 | 7/20 | 0.45 |
| ▸ | LCK | P06239 | 4/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162645 | 1.00 | RET (0.46) | RETKDRTEKLCKSRC | |
| SCHEMBL20162640 | 1.00 | RET (0.46) | RETKDRTEKLCKSRC | |
| SCHEMBL20162614 | 0.86 | RET (0.45) | RETKDRTEKLCKSRC | |
| SCHEMBL31099162 | 0.86 | RET (0.45) | RETKDRTEKLCKSRC | |
| SCHEMBL20162651 | 0.86 | KDR (0.46) | RETKDRTEKLCKSRC | |
| SCHEMBL30037546 | 0.86 | KDR (0.46) | RETKDRTEKLCKSRC | |
| SCHEMBL30538106 | 0.86 | KDR (0.46) | RETKDRTEKLCKSRC | |
| SCHEMBL20162649 | 0.86 | KDR (0.46) | RETKDRTEKLCKSRC | |
| SCHEMBL20173328 | 0.84 | KDR (0.45) | RETKDRTEKLCKSRC | |
| SCHEMBL20173325 | 0.84 | KDR (0.46) | RETKDRTEKLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | claimed |
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | disclosed |
| CN-110337294-B | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2022-11-01 | — | — | CN | disclosed |