Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.43 |
| ▸ | RET | P07949 | 5/20 | 0.36 |
| ▸ | SRC | P12931 | 4/20 | 0.35 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162736 | 1.00 | CFTR (0.43) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL20162599 | 0.90 | CFTR (0.55) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL30038252 | 0.90 | CFTR (0.55) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL30038234 | 0.90 | CFTR (0.55) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL20162597 | 0.90 | CFTR (0.55) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL20162851 | 0.89 | CFTR (0.45) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL30538123 | 0.89 | CFTR (0.45) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL30037060 | 0.86 | CFTR (0.46) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL20162970 | 0.86 | CFTR (0.46) | CFTRRETSRCEIF2AK3KDR | |
| SCHEMBL20162753 | 0.84 | CFTR (0.52) | CFTRRETSRCEIF2AK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | disclosed |
| CN-110337294-B | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2022-11-01 | — | — | CN | disclosed |