Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 9/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | TEK | Q02763 | 3/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ABL2 | P42684 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162713 | 1.00 | CFTR (0.46) | CFTRSRCALKEGFRKDR | |
| SCHEMBL20162784 | 1.00 | CFTR (0.46) | CFTRSRCALKEGFRKDR | |
| SCHEMBL20162716 | 0.92 | CFTR (0.50) | CFTRSRCEGFRKDRTEK | |
| SCHEMBL20162712 | 0.92 | CFTR (0.50) | CFTRSRCEGFRKDRTEK | |
| SCHEMBL30538085 | 0.92 | CFTR (0.50) | CFTRSRCEGFRKDRTEK | |
| SCHEMBL20162672 | 0.91 | CFTR (0.48) | CFTRSRCEGFRKDRABL1 | |
| SCHEMBL30036376 | 0.91 | CFTR (0.48) | CFTRSRCEGFRKDRABL1 | |
| SCHEMBL30538049 | 0.91 | CFTR (0.48) | CFTRSRCEGFRKDRABL1 | |
| SCHEMBL20162670 | 0.91 | CFTR (0.48) | CFTRSRCEGFRKDRABL1 | |
| SCHEMBL20162643 | 0.89 | CFTR (0.52) | CFTRSRCALKCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | claimed |
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | disclosed |
| CN-110337294-B | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2022-11-01 | — | — | CN | disclosed |