Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 14/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162641 | 1.00 | CFTR (0.56) | CFTRSRCPIK3CDNOTUMPI4KA | |
| SCHEMBL30538081 | 1.00 | CFTR (0.56) | CFTRSRCPIK3CDNOTUMPI4KA | |
| SCHEMBL20162639 | 1.00 | CFTR (0.56) | CFTRSRCPIK3CDNOTUMPI4KA | |
| SCHEMBL30038273 | 0.88 | CFTR (0.46) | CFTRNOTUMPI4KAPI4K2BPI4K2A | |
| SCHEMBL30538114 | 0.88 | CFTR (0.46) | CFTRNOTUMPI4KAPI4K2BPI4K2A | |
| SCHEMBL20162612 | 0.88 | CFTR (0.46) | CFTRNOTUMPI4KAPI4K2BPI4K2A | |
| SCHEMBL20162611 | 0.88 | CFTR (0.46) | CFTRNOTUMPI4KAPI4K2BPI4K2A | |
| SCHEMBL20162728 | 0.85 | CFTR (0.59) | CFTRSRCNOTUMPI4KAPI4K2B | |
| SCHEMBL30036823 | 0.85 | CFTR (0.59) | CFTRSRCNOTUMPI4KAPI4K2B | |
| SCHEMBL20162622 | 0.85 | CFTR (0.45) | CFTRSRCNOTUMPI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | claimed |
| CN-115850268-A | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2023-03-28 | — | — | CN | disclosed |
| CN-110337294-B | Pyrrolopyrimidines as CFTR potentiators | 囊性纤维化基金会 | 2022-11-01 | — | — | CN | disclosed |