Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035193 | 0.96 | WRN (0.47) | WRNTRPV1HDAC1MAPTPIK3CA | |
| SCHEMBL30039230 | 0.93 | WRN (0.52) | WRNTRPV1HDAC1 | |
| SCHEMBL30037825 | 0.91 | WRN (0.51) | WRNKMT2AMAPTPIK3CAMTOR | |
| SCHEMBL25035198 | 0.91 | TRPV1 (0.40) | TRPV1HDAC1KMT2AMAPTKDM4E | |
| SCHEMBL25036786 | 0.90 | WRN (0.54) | WRNTRPV1HDAC1KMT2AMAPT | |
| SCHEMBL27379214 | 0.89 | WRN (0.50) | WRNTRPV1KMT2AMAPTPIK3CA | |
| SCHEMBL25036831 | 0.88 | WRN (0.54) | WRNKMT2AMAPTMTORKDM4E | |
| SCHEMBL30038300 | 0.86 | WRN (0.51) | WRNTRPV1 | |
| SCHEMBL30038140 | 0.84 | WRN (0.58) | WRNMAPTPIK3CAMTORKDM4E | |
| SCHEMBL30037580 | 0.84 | WRN (0.51) | WRNKMT2AMAPTPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347596-A1 | TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN) | Novartis AG (CH) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022249060-A1 | TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN) | NOVARTIS AG (CH) | 2022-12-01 | — | — | WO | disclosed |