Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 3/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30038960 | 0.94 | WRN (0.50) | WRNMAPTALDH1A1DDR1BACE1 | |
| SCHEMBL25035212 | 0.94 | WRN (0.49) | WRNMAPTALDH1A1ENPP2BACE1 | |
| SCHEMBL30038096 | 0.94 | WRN (0.49) | WRNMAPTALDH1A1ENPP2BACE1 | |
| SCHEMBL30039143 | 0.92 | WRN (0.40) | WRNMAPTALDH1A1ENPP2BACE1 | |
| SCHEMBL30037486 | 0.91 | MAPT (0.40) | WRNMAPTALDH1A1DDR1WNT3A | |
| SCHEMBL30038821 | 0.90 | WRN (0.41) | WRNP2RX7KCNH2 | |
| SCHEMBL30038941 | 0.90 | WRN (0.44) | WRNMAPTALDH1A1ENPP2DDR1 | |
| SCHEMBL30038767 | 0.90 | WRN (0.40) | WRNMAPTALDH1A1BACE1 | |
| SCHEMBL30038237 | 0.89 | WRN (0.39) | WRNP2RX7 | |
| SCHEMBL30037935 | 0.89 | WRN (0.43) | WRNMAPTALDH1A1ENPP2DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347596-A1 | TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN) | Novartis AG (CH) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022249060-A1 | TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN) | NOVARTIS AG (CH) | 2022-12-01 | — | — | WO | disclosed |