Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.65 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30043261 | 1.00 | GRM5 (0.65) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL30044657 | 1.00 | GRM5 (0.65) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL30975217 | 1.00 | GRM5 (0.65) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL30044039 | 1.00 | GRM5 (0.65) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL30044931 | 1.00 | GRM5 (0.65) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL30043552 | 0.97 | GRM5 (0.61) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL30043283 | 0.97 | GRM5 (0.61) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL30044693 | 0.97 | GRM5 (0.61) | GRM5CNR2SMYD3CNR1CRBN | |
| SCHEMBL23425256 | 0.88 | GRM5 (0.68) | GRM5SMYD3CRBNCYP1A2GAA | |
| SCHEMBL7197995 | 0.88 | GRM5 (0.68) | GRM5SMYD3CRBNCYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743406-B9 | TMEM16A MODULATORS | TMEM16A LTD (GB) | 2023-03-08 | — | — | EP | claimed |
| EP-3743406-B1 | TMEM16A MODULATORS | TMEM16A LTD (GB) | 2022-12-28 | — | — | EP | claimed |