Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.84 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MERTK | Q12866 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30044697 | 0.92 | GRM5 (0.74) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL16394406 | 0.88 | GRM5 (0.88) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL31116604 | 0.87 | GRM5 (0.70) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL2246381 | 0.85 | GRM5 (0.82) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL25394287 | 0.85 | GRM5 (0.82) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL26923861 | 0.85 | GRM5 (0.82) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL26250579 | 0.85 | GRM5 (0.82) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL25394283 | 0.85 | GRM5 (0.82) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL2590689 | 0.84 | GRM5 (0.80) | GRM5SMYD3KDM4EGAAKMT2A | |
| SCHEMBL22449377 | 0.84 | GRM5 (0.80) | GRM5SMYD3KDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743406-B9 | TMEM16A MODULATORS | TMEM16A LTD (GB) | 2023-03-08 | — | — | EP | claimed |
| EP-3743406-B1 | TMEM16A MODULATORS | TMEM16A LTD (GB) | 2022-12-28 | — | — | EP | claimed |