Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.44 |
| ▸ | USP2 | O75604 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27162691 | 1.00 | TSHR (0.46) | TSHRCYP3A4CYP1A2CYP2D6USP2 | |
| SCHEMBL27162298 | 0.89 | POLB (0.51) | TSHRCYP3A4CYP1A2CYP2D6USP2 | |
| SCHEMBL30050265 | 0.89 | CYP3A4 (0.46) | TSHRCYP3A4CYP1A2CYP2D6USP2 | |
| SCHEMBL27161860 | 0.89 | CYP3A4 (0.46) | TSHRCYP3A4CYP1A2CYP2D6USP2 | |
| SCHEMBL27162687 | 0.88 | CYP2D6 (0.43) | TSHRCYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL30049132 | 0.88 | CYP2D6 (0.43) | TSHRCYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL30049764 | 0.88 | TSHR (0.45) | TSHRCYP3A4CYP1A2CYP2D6USP2 | |
| SCHEMBL30049872 | 0.88 | TSHR (0.45) | TSHRCYP3A4CYP1A2CYP2D6USP2 | |
| SCHEMBL27162655 | 0.88 | TSHR (0.45) | TSHRCYP3A4CYP1A2CYP2D6USP2 | |
| SCHEMBL27162034 | 0.88 | TSHR (0.45) | TSHRCYP3A4CYP1A2CYP2D6USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330248-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | Acondicionamiento Tarrasense (ES) | 2024-03-06 | — | — | EP | claimed |
| WO-2022229405-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2022-11-03 | — | — | WO | claimed |
| EP-4330248-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | Acondicionamiento Tarrasense (ES) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022229405-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2022-11-03 | — | — | WO | disclosed |