Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29186552 | 1.00 | EGFR (0.60) | EGFRPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL31060411 | 0.88 | PDGFRA (0.75) | EGFRPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL29186574 | 0.86 | KDR (0.52) | EGFRPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL30051051 | 0.86 | EGFR (0.50) | EGFRPDGFRAPDGFRBFGFR2 | |
| SCHEMBL29186584 | 0.86 | EGFR (0.50) | EGFRPDGFRAPDGFRBFGFR2 | |
| SCHEMBL21201045 | 0.85 | PDGFRA (0.59) | EGFRPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL30050441 | 0.81 | EGFR (0.58) | EGFRPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL27159593 | 0.81 | EGFR (0.58) | EGFRPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL7486400 | 0.79 | FGFR2 (0.84) | EGFRPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL29186559 | 0.79 | PDGFRA (0.61) | EGFRPDGFRAPDGFRBFGFR2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330233-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022228549-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2022-11-03 | — | — | WO | disclosed |