SCHEMBL30059005

SCHEMBL30059005

CCS(=O)(=O)Nc1cc(COC)ccc1Nc1cc(NC(=O)C2CC2)nc2[nH]n(C)c(=O)c12

nearest known ligand 0.77

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 20/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21353989 1.00 TYK2 (0.77) TYK2
SCHEMBL30057284 0.92 TYK2 (0.77) TYK2
SCHEMBL20212509 0.92 TYK2 (0.77) TYK2
SCHEMBL20212515 0.88 TYK2 (0.66) TYK2
SCHEMBL20073229 0.87 TYK2 (0.83) TYK2
SCHEMBL20212508 0.87 TYK2 (0.70) TYK2
SCHEMBL30059439 0.87 TYK2 (0.70) TYK2
SCHEMBL29883900 0.87 TYK2 (1.00) TYK2
SCHEMBL20073268 0.87 TYK2 (1.00) TYK2
SCHEMBL30059114 0.87 TYK2 (0.70) TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115448916-A TYK2 inhibitor and application thereof 林伯士拉克许米公司 2022-12-09 CN disclosed