Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 15/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 11/20 | 0.47 |
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23292657 | 1.00 | NTRK1 (0.47) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL30062280 | 0.83 | NTRK1 (0.62) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL23292620 | 0.83 | NTRK1 (0.62) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL30060207 | 0.80 | NTRK1 (0.61) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL23292654 | 0.80 | NTRK1 (0.61) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL23292598 | 0.77 | NTRK1 (0.40) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL23292643 | 0.75 | NTRK1 (0.60) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL30061600 | 0.75 | NTRK1 (0.60) | NTRK1NTRK2NTRK3IGF1RFGFR1 | |
| SCHEMBL30965498 | 0.75 | MAPT (0.41) | BRD4MAPTALDH1A1LMNAHTT | |
| SCHEMBL24065488 | 0.75 | MAPT (0.41) | BRD4MAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513032-B | 4-Substituted phenyl-1, 3, 5-triazine derivatives as modulators of TRK receptors | 阿泽克制药公司 | 2024-07-02 | — | — | CN | claimed |
| EP-3814335-B1 | 4-SUBSTITUTED PHENYL-1,3,5-TRIAZINE DERIVATIVES AS MODULATORS OF TRK RECEPTORS | AlzeCure Pharma AB (SE) | 2022-11-09 | — | — | EP | claimed |
| CN-112513032-B | 4-Substituted phenyl-1, 3, 5-triazine derivatives as modulators of TRK receptors | 阿泽克制药公司 | 2024-07-02 | — | — | CN | disclosed |