Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.77 |
| ▸ | JAK2 | O60674 | 6/20 | 0.77 |
| ▸ | JAK1 | P23458 | 4/20 | 0.69 |
| ▸ | STAT3 | P40763 | 2/20 | 0.69 |
| ▸ | JAK3 | P52333 | 2/20 | 0.69 |
| ▸ | STAT1 | P42224 | 1/20 | 0.69 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22313324 | 1.00 | TYK2 (0.77) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL30065932 | 0.94 | TYK2 (0.78) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL30065955 | 0.87 | TYK2 (0.75) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL22288328 | 0.87 | TYK2 (0.75) | TYK2JAK2JAK1STAT3JAK3 | |
| Cravacitinib SCHEMBL21091048 | 0.87 | TYK2 (1.00) | TYK2JAK2JAK1STAT3JAK3 | |
| Cravacitinib SCHEMBL30465860 | 0.87 | TYK2 (1.00) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL22313977 | 0.85 | TYK2 (0.59) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL26041867 | 0.82 | TYK2 (0.77) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL25759743 | 0.82 | TYK2 (0.88) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL28665049 | 0.82 | TYK2 (0.66) | TYK2JAK2JAK1STAT3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448910-A | Pyridazine derivative inhibitor, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-12-09 | — | — | CN | disclosed |