Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | BCL6 | P41182 | 11/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30067008 | 0.75 | CDC7 (0.42) | RXFP1HTT | |
| SCHEMBL23474006 | 0.75 | CYP3A4 (0.48) | RXFP1BCL6NPC1RAB9AMAPT | |
| SCHEMBL29196668 | 0.73 | RXFP1 (0.42) | RXFP1BCL6MAPTLMNASMN1; SMN2 | |
| SCHEMBL30855433 | 0.73 | RXFP1 (0.42) | RXFP1BCL6MAPTLMNASMN1; SMN2 | |
| SCHEMBL29861403 | 0.73 | HSD17B10 (0.33) | RXFP1MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL23326744 | 0.73 | HSD17B10 (0.33) | RXFP1MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL23479477 | 0.71 | RXFP1 (0.41) | RXFP1BCL6MAPTLMNACYP2C19 | |
| SCHEMBL23478503 | 0.71 | RXFP1 (0.41) | RXFP1BCL6MAPTLMNAKDM4E | |
| SCHEMBL16795077 | 0.71 | RXFP1 (0.41) | RXFP1BCL6MAPTLMNACYP2C19 | |
| SCHEMBL16809631 | 0.70 | RHEB (0.46) | RXFP1BCL6NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117062818-A | Novel SOS1 inhibitor and preparation method and application thereof | 南京再明医药有限公司 | 2023-11-14 | — | — | CN | disclosed |
| WO-2022184116-A1 | NEW SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏先声药业有限公司 | 2022-09-09 | — | — | WO | disclosed |