Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.69 |
| ▸ | FGFR2 | P21802 | 11/20 | 0.69 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19950000 | 1.00 | FGFR1 (0.69) | FGFR1FGFR2MAP4K1FGFR4FGFR3 | |
| SCHEMBL19950152 | 0.93 | MAP4K1 (0.60) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL30069603 | 0.93 | MAP4K1 (0.60) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL19950132 | 0.92 | MAP4K1 (0.74) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL30069685 | 0.91 | MAP4K1 (0.62) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL19950406 | 0.91 | MAP4K1 (0.62) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL19950660 | 0.91 | MAP4K1 (0.62) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL24979299 | 0.90 | MAP4K1 (0.62) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL19950074 | 0.90 | MAP4K1 (0.62) | FGFR1FGFR2MAP4K1KITFLT3 | |
| SCHEMBL29746704 | 0.90 | MAP4K1 (0.62) | FGFR1FGFR2MAP4K1KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109923114-B | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2022-11-01 | — | — | CN | claimed |
| CN-115819417-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4119558-A1 | PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF | Incyte Corporation (US) | 2023-01-18 | — | — | EP | disclosed |