Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 14/20 | 0.84 |
| ▸ | PIM1 | P11309 | 5/20 | 0.50 |
| ▸ | WNT1 | P04628 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19950245 | 1.00 | MAP4K1 (0.84) | MAP4K1PIM1WNT1TGFBR1PIM3 | |
| SCHEMBL19950219 | 0.94 | MAP4K1 (0.78) | MAP4K1PIM1WNT1TGFBR1 | |
| SCHEMBL30069610 | 0.94 | MAP4K1 (0.78) | MAP4K1PIM1WNT1TGFBR1 | |
| SCHEMBL19950318 | 0.93 | MAP4K1 (0.77) | MAP4K1PIM1WNT1TGFBR1PIM3 | |
| SCHEMBL30069587 | 0.93 | MAP4K1 (0.77) | MAP4K1PIM1WNT1TGFBR1PIM3 | |
| SCHEMBL19950328 | 0.92 | MAP4K1 (0.72) | MAP4K1PIM1 | |
| SCHEMBL30069645 | 0.92 | MAP4K1 (0.72) | MAP4K1PIM1 | |
| SCHEMBL19950188 | 0.92 | MAP4K1 (1.00) | MAP4K1 | |
| SCHEMBL19950083 | 0.92 | MAP4K1 (0.75) | MAP4K1PIM1WNT1TGFBR1PIM3 | |
| SCHEMBL30069624 | 0.92 | MAP4K1 (0.75) | MAP4K1PIM1WNT1TGFBR1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109923114-B | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2022-11-01 | — | — | CN | claimed |
| CN-115819417-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |