Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17303577 | 1.00 | LOX (0.55) | LOXLOXL2LRRK2KDM4EALDH1A1 | |
| SCHEMBL6890599 | 0.96 | LOX (0.59) | LOXLOXL2LRRK2KDM4EALDH1A1 | |
| SCHEMBL16453455 | 0.94 | LOX (0.53) | LOXLOXL2LRRK2KDM4EALDH1A1 | |
| SCHEMBL15829858 | 0.86 | SYK (0.48) | LOXLOXL2LRRK2HCRTR1HCRTR2 | |
| SCHEMBL8277607 | 0.86 | HDAC6 (0.50) | LOXLOXL2LRRK2HCRTR1HCRTR2 | |
| SCHEMBL427767 | 0.85 | LRRK2 (0.48) | LOXLOXL2LRRK2HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL5335017 | 0.85 | SYK (0.47) | LOXLOXL2HCRTR1HCRTR2AXL | |
| SCHEMBL631617 | 0.85 | LOX (0.46) | LOXLOXL2LRRK2KDM4EALDH1A1 | |
| SCHEMBL15651656 | 0.84 | LOX (0.58) | LOXLOXL2LRRK2PDGFRBPDGFRA | |
| SCHEMBL20909924 | 0.82 | LOX (0.42) | LOXLOXL2LRRK2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113105475-B | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2022-09-09 | — | — | CN | disclosed |