Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.82 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.82 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL301011 | 0.91 | PDE4A (0.96) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL187090 | 0.91 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL300637 | 0.89 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4D | |
| Carbamic Acid SCHEMBL300981 | 0.89 | PDE4A (0.93) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL300979 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL300715 | 0.88 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL300759 | 0.88 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL301001 | 0.86 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL300747 | 0.85 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL187628 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146989-B1 | TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES | LEO PHARMA AS (DK) | 2012-01-04 | — | — | EP | claimed |