Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.58 |
| ▸ | HTR2C | P28335 | 17/20 | 0.58 |
| ▸ | HTR2B | P41595 | 17/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL183333 | 0.99 | HTR2A (0.57) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| SCHEMBL300649 | 0.91 | HTR2A (0.58) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| Hydrochloric Acid SCHEMBL183525 | 0.90 | HTR2A (0.57) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| SCHEMBL183820 | 0.82 | HTR2A (0.62) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| SCHEMBL3410880 | 0.82 | HTR2A (0.62) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| SCHEMBL10272958 | 0.80 | HTR2A (0.59) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| SCHEMBL27742312 | 0.80 | HTR2A (0.59) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| Hydrochloric Acid SCHEMBL183334 | 0.79 | HTR2A (0.58) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| SCHEMBL183910 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BHRH2HRH3 | |
| SCHEMBL183539 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BHRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928461-B1 | PYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-01-04 | — | — | EP | claimed |