Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 6/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27142615 | 0.94 | PIM1 (0.47) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL27518105 | 0.92 | PIM1 (0.52) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL13537761 | 0.88 | PIM1 (0.53) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL12283785 | 0.88 | PIM1 (0.52) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL12283853 | 0.88 | PIM1 (0.52) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL12283734 | 0.88 | PIM1 (0.52) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL27591404 | 0.87 | PIM1 (0.49) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL27572723 | 0.87 | PIM1 (0.49) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL12284134 | 0.87 | PIM1 (0.52) | PIM1PIM3PIM2CTSKCKS1B | |
| SCHEMBL30079063 | 0.86 | PIM1 (0.48) | PIM1PIM3PIM2CTSKCKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |