Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.74 |
| ▸ | KIT | P10721 | 9/20 | 0.73 |
| ▸ | EGFR | P00533 | 4/20 | 0.67 |
| ▸ | CSF1R | P07333 | 5/20 | 0.67 |
| ▸ | RET | P07949 | 4/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19471824 | 1.00 | BRAF (0.74) | BRAFKITEGFRCSF1RRET | |
| SCHEMBL29562470 | 0.90 | BRAF (0.82) | BRAFKITEGFRCSF1RRET | |
| SCHEMBL6184307 | 0.90 | BRAF (0.82) | BRAFKITEGFRCSF1RRET | |
| SCHEMBL589012 | 0.89 | KIT (0.75) | BRAFKITEGFRCSF1RRET | |
| SCHEMBL14318406 | 0.89 | KIT (0.77) | BRAFKITEGFRCSF1RABL1 | |
| SCHEMBL29562197 | 0.89 | KIT (0.77) | BRAFKITEGFRCSF1RABL1 | |
| Hydrochloric Acid SCHEMBL29833672 | 0.88 | KIT (0.75) | BRAFKITEGFRCSF1RABL1 | |
| SCHEMBL15690062 | 0.87 | KIT (0.69) | BRAFKITEGFRCSF1RRET | |
| SCHEMBL15847281 | 0.87 | RET (0.71) | BRAFKITEGFRRET | |
| SCHEMBL12871531 | 0.87 | KIT (0.84) | BRAFKITEGFRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246327-B1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIV (CN) | 2022-11-23 | — | — | EP | disclosed |