Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 15/20 | 0.85 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.85 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.85 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.85 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300810 | 1.00 | PIK3CB (0.85) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL301304 | 0.92 | PIK3CB (0.85) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL300794 | 0.92 | PIK3CB (0.85) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL300949 | 0.92 | PIK3CB (1.00) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL301238 | 0.91 | PIK3CB (0.98) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL301311 | 0.90 | PIK3CB (0.85) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL300900 | 0.90 | PIK3CB (0.84) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL300840 | 0.89 | PIK3CB (0.80) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL300841 | 0.89 | PIK3CB (0.80) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 | |
| SCHEMBL301214 | 0.89 | PIK3CB (0.80) | PIK3CBPIK3CGPIK3CDPIK3CACSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-107976546-B | Inhibition of phosphorylation of TOR kinase inhibitory Activity markers PRAS40, GSK 3-beta, or P70S6K1 | 西格诺药品有限公司 | 2020-10-27 | — | — | CN | disclosed |
| CN-110721186-A | Treatment of prostate cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-24 | — | — | CN | disclosed |
| CN-107157990-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-104271139-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271138-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |