Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 10/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300837 | 1.00 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL300836 | 1.00 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL300862 | 0.90 | PIK3CA (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL301177 | 0.87 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL301178 | 0.87 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL300917 | 0.84 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL300916 | 0.84 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL300840 | 0.83 | PIK3CB (0.80) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL301214 | 0.83 | PIK3CB (0.80) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 | |
| SCHEMBL300841 | 0.83 | PIK3CB (0.80) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |