SCHEMBL30086902

SCHEMBL30086902

[2H]C([2H])([2H])n1cc(-c2cc(Oc3ccc(N)nc3)ccn2)cn1

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 20/20 0.47
▸ PDGFRA P16234 8/20 0.47
▸ KIT P10721 8/20 0.47
▸ FLT3 P36888 2/20 0.47
▸ PDGFRB P09619 6/20 0.46
▸ MET P08581 3/20 0.45
▸ KDR P35968 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16029169 1.00 CSF1R (0.47) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL30086949 0.92 CSF1R (0.54) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL2416158 0.92 CSF1R (0.54) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL16028873 0.82 CSF1R (0.52) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL23900476 0.81 CSF1R (0.41) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL30086972 0.81 PIM1 (0.51) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL23888703 0.81 PIM1 (0.51) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL574068 0.79 KDR (0.52) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL29736768 0.79 KDR (0.52) CSF1RPDGFRAKITFLT3PDGFRB
SCHEMBL16029060 0.79 CSF1R (0.51) CSF1RPDGFRAKITFLT3PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4126844-A1 AMIDE COMPOUNDS AND USES THEREOF Hutchison Medipharma Limited (CN) 2023-02-08 — — EP disclosed
CN-115315422-A Amide compound and application thereof 和记黄埔医药(上海)有限公司 2022-11-08 — — CN disclosed
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