Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185941 | 0.91 | TRPV1 (0.40) | TRPV1LIMK1LIMK2 | |
| SCHEMBL186106 | 0.87 | TRPV1 (0.39) | TRPV1SIGMAR1LIMK1LIMK2 | |
| SCHEMBL18576998 | 0.86 | TRPV1 (0.40) | TRPV1LIMK1LIMK2 | |
| SCHEMBL186091 | 0.86 | GRIN2B (0.39) | TRPV1ATM | |
| SCHEMBL186996 | 0.84 | TRPV1 (0.39) | TRPV1LIMK1LIMK2 | |
| SCHEMBL300615 | 0.83 | TRPV1 (0.40) | TRPV1LIMK1LIMK2 | |
| SCHEMBL187250 | 0.83 | TRPV1 (0.41) | TRPV1LMNAMAPTLIMK1LIMK2 | |
| SCHEMBL185519 | 0.82 | TRPV1 (0.39) | TRPV1CCNT1CDK9LIMK1LIMK2 | |
| SCHEMBL300746 | 0.82 | TRPV1 (0.37) | TRPV1ATMLIMK1LIMK2 | |
| SCHEMBL1980874 | 0.81 | ATM (0.39) | TRPV1ATML3MBTL1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297148-B1 | NOVEL DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALCANONE AND USE THEREOF AS P75 INHIBITORS | SANOFI SA (FR) | 2012-01-04 | — | — | EP | claimed |