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SCHEMBL30091022

SCHEMBL30091022

CC(C)(C)[Si](OC[C@H]1O[C@@](C#N)(c2ccc3c(NC(=O)c4ccccc4)ncnn23)[C@H](O)[C@@H]1O)(c1ccccc1)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TMPRSS2 O15393 1/20 0.59
▸ CYP3A4 P08684 1/20 0.34
▸ EGLN2 Q96KS0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30090991 0.89 TMPRSS2 (0.48) TMPRSS2CYP3A4EGLN2
SCHEMBL30931380 0.89 TMPRSS2 (0.48) TMPRSS2CYP3A4EGLN2
SCHEMBL30090993 0.89 TMPRSS2 (0.48) TMPRSS2CYP3A4
SCHEMBL30091026 0.87 TMPRSS2 (0.46) TMPRSS2
SCHEMBL24789731 0.86 TMPRSS2 (0.64) TMPRSS2EGLN2
SCHEMBL30091044 0.86 TMPRSS2 (0.46) TMPRSS2CYP3A4
SCHEMBL25909952 0.85 TMPRSS2 (0.68) TMPRSS2CYP3A4EGLN2
SCHEMBL24789739 0.85 TMPRSS2 (0.62) TMPRSS2EGLN2
SCHEMBL24916989 0.85 TMPRSS2 (0.62) TMPRSS2EGLN2
SCHEMBL24789736 0.85 TMPRSS2 (0.58) TMPRSS2EGLN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118139868-A Orally bioavailable nucleoside analogs 维纳拓尔斯制药公司 2024-06-04 — — CN disclosed
EP-4355755-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS Venatorx Pharmaceuticals, Inc. (US) 2024-04-24 — — EP disclosed
WO-2022265964-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS VenatoRx Pharmaceuticals, Inc. (US) 2022-12-22 — — WO disclosed
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