Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22272596 | 1.00 | DYRK1A (0.52) | DYRK1AMGAMGAASIMGAM2 | |
| SCHEMBL3361169 | 0.80 | DYRK1A (0.60) | DYRK1AGSK3BNOS3NOS1NOS2 | |
| SCHEMBL320181 | 0.78 | DYRK1A (0.54) | DYRK1AGSK3BNOS3NOS1NOS2 | |
| SCHEMBL23927489 | 0.77 | DYRK1A (0.48) | DYRK1AGSK3BNOS3NOS1NOS2 | |
| SCHEMBL30091458 | 0.77 | DYRK1A (0.48) | DYRK1AGSK3BNOS3NOS1NOS2 | |
| SCHEMBL6496645 | 0.76 | GAA (0.51) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL31381034 | 0.76 | DYRK1A (0.73) | DYRK1AGSK3BNOS3NOS1NOS2 | |
| SCHEMBL16371252 | 0.75 | DYRK1A (0.55) | DYRK1AGAAGSK3BNOS3NOS1 | |
| SCHEMBL4215294 | 0.75 | CDK5 (0.52) | DYRK1AMGAMGAASIMGAM2 | |
| SCHEMBL14125145 | 0.74 | GAA (0.56) | MGAMGAASIMGAM2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166116-B | Amido bridged heterocyclic compound, and composition and application thereof | 北京赛特明强医药科技有限公司 | 2022-12-27 | — | — | CN | disclosed |