Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 11/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 11/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16946775 | 1.00 | NTRK1 (0.53) | NTRK1NTRK3NTRK2KDM4ENPC1 | |
| SCHEMBL29617203 | 0.86 | NTRK1 (0.51) | NTRK1NTRK3NTRK2KDM4ENPC1 | |
| SCHEMBL16935988 | 0.83 | NTRK1 (0.49) | NTRK1NTRK3NTRK2KDM4ENPC1 | |
| SCHEMBL29511265 | 0.83 | NTRK1 (0.49) | NTRK1NTRK3NTRK2KDM4ENPC1 | |
| SCHEMBL29511282 | 0.82 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29511254 | 0.82 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL16946698 | 0.82 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL16946773 | 0.82 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL19614333 | 0.80 | KDM4E (0.42) | NTRK1NTRK3NTRK2KDM4ENPC1 | |
| SCHEMBL16946767 | 0.80 | NTRK1 (0.45) | NTRK1NTRK3NTRK2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4338739-A2 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| EP-3636649-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TURNING POINT THERAPEUTICS INC (US) | 2024-02-14 | — | — | EP | disclosed |
| EP-3572416-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TURNING POINT THERAPEUTICS INC (US) | 2022-09-21 | — | — | EP | disclosed |