Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PDE8B | O95263 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29174974 | 1.00 | PDE10A (0.39) | PDE10AADORA2AADORA1PDE8BHSP90AA1 | |
| SCHEMBL30095986 | 0.85 | ADORA2A (0.39) | ADORA2AADORA1HSP90AA1TRAP1HSP90B1 | |
| SCHEMBL29174930 | 0.84 | ADORA2A (0.37) | ADORA2AADORA1PDE8BHSP90AA1TRAP1 | |
| SCHEMBL30748232 | 0.84 | ADORA2A (0.37) | ADORA2AADORA1PDE8BHSP90AA1TRAP1 | |
| SCHEMBL30095812 | 0.84 | ADORA2A (0.37) | ADORA2AADORA1PDE8BPDE1APDE1B | |
| SCHEMBL29174959 | 0.84 | ADORA2A (0.37) | ADORA2AADORA1PDE8BPDE1APDE1B | |
| SCHEMBL30095904 | 0.84 | PDE10A (0.43) | PDE10AADORA2AADORA1PDE8BHSP90AA1 | |
| SCHEMBL29174904 | 0.84 | PDE10A (0.43) | PDE10AADORA2AADORA1PDE8BHSP90AA1 | |
| SCHEMBL25876077 | 0.81 | MERTK (0.35) | PDE10AHSP90AA1TRAP1HSP90B1ALDH1A1 | |
| SCHEMBL29174835 | 0.80 | PDE9A (0.41) | PDE10APDE8BHSP90AA1TRAP1PDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346806-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | Biocryst Pharmaceuticals, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117529315-A | Imidazole-containing ALK2 kinase inhibitors | 生物水晶制药公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2022251188-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2022-12-01 | — | — | WO | disclosed |