Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 2/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29174763 | 1.00 | LRRK2 (0.38) | LRRK2ADORA3ADORA2AADORA1MAT2A | |
| SCHEMBL29174930 | 0.87 | ADORA2A (0.37) | LRRK2ADORA2AADORA1PDE1APDE1B | |
| SCHEMBL30748232 | 0.87 | ADORA2A (0.37) | LRRK2ADORA2AADORA1PDE1APDE1B | |
| SCHEMBL30095933 | 0.87 | PDE1A (0.39) | PDE1APDE1BPDE1C | |
| SCHEMBL30748206 | 0.86 | PDE1A (0.38) | PDE1APDE1BPDE1C | |
| SCHEMBL30095754 | 0.85 | PDE9A (0.39) | ADORA1PDE1C | |
| SCHEMBL29174800 | 0.85 | PDE9A (0.39) | ADORA1PDE1C | |
| SCHEMBL30748235 | 0.83 | PDE2A (0.40) | — | |
| SCHEMBL29174794 | 0.83 | PDE2A (0.40) | — | |
| SCHEMBL29174904 | 0.81 | PDE10A (0.43) | LRRK2ADORA3ADORA2AADORA1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346806-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | Biocryst Pharmaceuticals, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117529315-A | Imidazole-containing ALK2 kinase inhibitors | 生物水晶制药公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2022251188-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2022-12-01 | — | — | WO | disclosed |