Sugi Predict

Sugi Predict / Compounds / SCHEMBL30097352

SCHEMBL30097352

SCHEMBL30097352

CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ AKT1 P31749 11/20 1.00
▸ RPS6KB1 P23443 10/20 1.00
▸ AKT2 P31751 1/20 1.00
▸ AKT3 Q9Y243 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4725524 1.00 AKT1 (1.00) AKT1RPS6KB1AKT2AKT3
SCHEMBL4917931 0.93 AKT1 (0.88) AKT1RPS6KB1AKT2AKT3
SCHEMBL4725153 0.93 AKT1 (0.86) AKT1RPS6KB1AKT2AKT3
SCHEMBL4726182 0.92 AKT1 (0.85) AKT1RPS6KB1AKT2AKT3
SCHEMBL4725403 0.92 AKT1 (0.85) AKT1RPS6KB1AKT2AKT3
SCHEMBL4776861 0.91 AKT1 (0.84) AKT1RPS6KB1AKT2AKT3
SCHEMBL4778332 0.91 AKT1 (1.00) AKT1RPS6KB1AKT2AKT3
SCHEMBL4727021 0.91 AKT1 (0.83) AKT1RPS6KB1AKT2AKT3
SCHEMBL4725325 0.90 AKT1 (0.83) AKT1RPS6KB1AKT2AKT3
SCHEMBL4782194 0.89 AKT1 (1.00) AKT1RPS6KB1AKT2AKT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4308691-A1 METHODS FOR TUMOR INFILTRATING LYMPHOCYTE (TIL) EXPANSION RELATED TO CD39/CD69 SELECTION AND GENE KNOCKOUT IN TILS Iovance Biotherapeutics, Inc. (US) 2024-01-24 — — EP disclosed
WO-2022198141-A1 METHODS FOR TUMOR INFILTRATING LYMPHOCYTE (TIL) EXPANSION RELATED TO CD39/CD69 SELECTION AND GENE KNOCKOUT IN TILS IOVANCE BIOTHERAPEUTICS, INC. (US) 2022-09-22 — — WO disclosed