Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23704509 | 1.00 | TLR7 (0.54) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL23704513 | 0.93 | TLR7 (0.55) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL26412750 | 0.90 | TLR7 (0.42) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL23718948 | 0.89 | TLR7 (0.59) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL23704425 | 0.88 | TLR7 (0.43) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL29971148 | 0.88 | TLR7 (0.42) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL23718947 | 0.88 | TLR7 (0.61) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL23718889 | 0.88 | TLR7 (0.42) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL23703428 | 0.87 | TLR7 (0.56) | TLR7KCNH2CYP3A4CYP2D6 | |
| SCHEMBL23718976 | 0.87 | TLR7 (0.72) | TLR7KCNH2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4097104-A1 | 1H-PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | Bristol-Myers Squibb Company (US) | 2022-12-07 | — | — | EP | disclosed |
| CN-115210235-A | 1H-pyrazolo [4,3-d ] pyrimidine compounds as Toll-like receptor 7 (TLR 7) agonists | 百时美施贵宝公司 | 2022-10-18 | — | — | CN | disclosed |