Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 3/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22275062 | 1.00 | PDE9A (0.42) | PDE9AKDM4EKDM5AKDM5CKDM5B | |
| SCHEMBL25389897 | 0.85 | KDM5A (0.49) | PDE9AKDM5AKDM5CKDM5BLMNA | |
| SCHEMBL31298163 | 0.82 | KDM5A (0.43) | PDE9AKDM5AKDM5CKDM5BLMNA | |
| SCHEMBL4754780 | 0.80 | PDE9A (0.60) | PDE9AKDM4EKDM5AKDM5CKDM5B | |
| SCHEMBL22275250 | 0.74 | PDE9A (0.64) | PDE9A | |
| SCHEMBL20870664 | 0.72 | PDE9A (0.60) | PDE9AKDM4EKDM5AKDM5CKDM5B | |
| SCHEMBL22275077 | 0.71 | PDE9A (0.65) | PDE9A | |
| SCHEMBL21840104 | 0.71 | KDM4E (0.38) | PDE9AKDM4ELMNAHPGDALDH1A1 | |
| SCHEMBL1790858 | 0.69 | KDM4E (0.41) | KDM4ELMNAALDH1A1CYP1A2PDE2A | |
| SCHEMBL1621734 | 0.69 | PDE9A (0.62) | PDE9AKDM4ELMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471059-B | PDE9 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-12-02 | — | — | CN | disclosed |