Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 18/20 | 0.73 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.73 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.73 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.73 |
| ▸ | KCNMB1 | Q16558 | 1/20 | 0.73 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25266756 | 1.00 | KCNT1 (0.73) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL25214282 | 1.00 | KCNT1 (0.73) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL25601397 | 0.94 | KCNT1 (0.72) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL25244088 | 0.94 | KCNT1 (0.71) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL25244089 | 0.94 | KCNT1 (0.71) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL25245935 | 0.91 | KCNT1 (0.71) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL25245937 | 0.91 | KCNT1 (0.71) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637565 | 0.90 | KCNT1 (0.71) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637564 | 0.90 | KCNT1 (0.71) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637896 | 0.90 | KCNT1 (0.71) | KCNT1KCNQ1KCNH2CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110317-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| CN-115443129-A | KCNT1 inhibitors and methods of use | 普拉西斯精密医药公司 | 2022-12-06 | — | — | CN | disclosed |