Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.60 |
| ▸ | RAF1 | P04049 | 5/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.55 |
| ▸ | ARAF | P10398 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13267928 | 0.93 | BRAF (0.51) | BRAFRAF1MAPK3ARAFKDR | |
| SCHEMBL3021374 | 0.91 | BRAF (0.62) | BRAFRAF1ARAF | |
| SCHEMBL3010053 | 0.91 | BRAF (0.49) | BRAFRAF1MAPK3ARAFKDR | |
| SCHEMBL3020745 | 0.90 | BRAF (0.48) | BRAFRAF1MAPK3KDRMAPK14 | |
| SCHEMBL3016350 | 0.88 | BRAF (0.49) | BRAFRAF1MAPK3ARAFKDR | |
| SCHEMBL3594600 | 0.87 | BRAF (0.60) | BRAFRAF1MAPK3ARAFKDR | |
| SCHEMBL3017721 | 0.86 | KDR (0.56) | BRAFRAF1MAPK3KDRMAPK14 | |
| SCHEMBL3016479 | 0.85 | KDR (0.46) | BRAFRAF1MAPK3KDRMAPK14 | |
| SCHEMBL3592095 | 0.84 | BRAF (0.57) | BRAFRAF1MAPK3ARAFKDR | |
| SCHEMBL3013648 | 0.84 | KDR (0.46) | BRAFRAF1MAPK3KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | claimed |
| EP-2170867-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2010-04-07 | — | — | EP | claimed |
| WO-2008157131-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | claimed |
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | disclosed |
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | disclosed |
| EP-2170867-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157131-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | BMX, FRK, FYN | BRAF 33/4885RAF1 21/4885MAPK3 386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.