Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 14/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15261632 | 0.82 | PIM1 (0.45) | PIM1PIM2RETKDR | |
| SCHEMBL15261764 | 0.81 | PIM1 (0.44) | PIM1PIM2RETIRAK4 | |
| SCHEMBL17464320 | 0.81 | RET (0.38) | PIM1PIM2RETKDR | |
| SCHEMBL15261465 | 0.78 | PIM1 (0.44) | PIM1PIM2RETKDR | |
| SCHEMBL19467147 | 0.78 | PIM1 (0.39) | PIM1PIM2RETKDRIRAK4 | |
| SCHEMBL15894555 | 0.78 | SUV39H2 (0.51) | PIM1PIM2RETIRAK4 | |
| SCHEMBL4333039 | 0.77 | RET (0.45) | PIM1PIM2RETKDR | |
| SCHEMBL15891337 | 0.77 | PIM1 (0.61) | PIM1PIM2RETIRAK4 | |
| SCHEMBL15891411 | 0.77 | RET (0.53) | PIM1PIM2RET | |
| SCHEMBL15280689 | 0.76 | RET (0.48) | PIM1PIM2RETKDRIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427045-A | 4- (3- (pyridin-3-yl) pyrazolo [1,5-a ] pyrimidin-5-yl) piperazine for the treatment of COV-229E or COV-OC43 coronavirus infection | 莱西肯医药有限公司 | 2022-12-02 | — | — | CN | disclosed |