Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL3662105 | 0.90 | MAPT (0.39) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| Iodide SCHEMBL17350237 | 0.90 | MAPT (0.39) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| Iodide SCHEMBL29072731 | 0.89 | MAPT (0.39) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| Iodide SCHEMBL2682814 | 0.88 | MAPT (0.39) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL3786410 | 0.87 | MAPT (0.38) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| Iodide SCHEMBL5918788 | 0.86 | MAPT (0.38) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL3944198 | 0.85 | MAPT (0.36) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL3944197 | 0.85 | MAPT (0.36) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL13983891 | 0.84 | MAPT (0.36) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| Iodide SCHEMBL30216122 | 0.84 | MAPT (0.40) | MEN1MAPTHTTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455209-B2 | Reagent and reagent kit for analysis of immature leukocyte | SYSMEX CORPORATION (JP) | 2013-06-04 | — | — | US | claimed |
| US-20100184061-A1 | REAGENT AND REAGENT KIT FOR ANALYSIS OF IMMATURE LEUKOCYTE | SYSMEX CORORATION (JP) | 2010-07-22 | — | — | US | claimed |
| EP-2166353-A1 | REAGENT AND REAGENT KIT FOR ANALYSIS OF PRIMITIVE LEUKOCYTE | Sysmex Corporation (JP) | 2010-03-24 | — | — | EP | claimed |
| US-10578603-B2 | Blood analyzer, blood analyzing method, and non-transitory storage medium | SYSMEX CORPORATION (JP) | 2020-03-03 | — | — | US | disclosed |
| US-20150369793-A1 | BLOOD ANALYZER, BLOOD ANALYZING METHOD, AND NON-TRANSITORY STORAGE MEDIUM | SYSMEX CORPORATION (JP) | 2015-12-24 | — | — | US | disclosed |
| US-8455209-B2 | Reagent and reagent kit for analysis of immature leukocyte | SYSMEX CORPORATION (JP) | 2013-06-04 | — | — | US | disclosed |
| US-20100184061-A1 | REAGENT AND REAGENT KIT FOR ANALYSIS OF IMMATURE LEUKOCYTE | SYSMEX CORORATION (JP) | 2010-07-22 | — | — | US | disclosed |