Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 5/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060363 | 0.95 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1059217 | 0.91 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL3010382 | 0.91 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1065137 | 0.90 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1066925 | 0.89 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1060756 | 0.88 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1066827 | 0.88 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1065206 | 0.87 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL1063681 | 0.87 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL10204239 | 0.87 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4524072-B2 | — | — | 2010-08-11 | — | — | JP | claimed |
| EP-1333833-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-10-24 | — | — | EP | claimed |
| EP-1333833-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-08-13 | — | — | EP | claimed |
| WO-2002059083-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-01 | — | — | WO | claimed |