Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.43 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296302 | 0.81 | MAPK14 (0.64) | PTK2MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5998813 | 0.75 | MAPK14 (0.34) | CDK8MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL6452416 | 0.74 | MAPK9 (0.51) | CDK8PTK2MAPK14MAPK12MAPK13 | |
| SCHEMBL5990657 | 0.74 | MAPK9 (0.46) | CDK8PTK2MAPK14MAPK12MAPK13 | |
| SCHEMBL6284852 | 0.74 | TNF (0.33) | MAPK14MAPK12HCKTNF | |
| SCHEMBL18546331 | 0.74 | MAPK14 (0.53) | CDK8MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL6275274 | 0.73 | RAF1 (0.40) | PTK2MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5989034 | 0.73 | MAPK9 (0.55) | CDK8PTK2MAPK14MAPK12MAPK13 | |
| SCHEMBL17237755 | 0.73 | MAPK14 (0.67) | CDK8PTK2MAPK14MAPK12MAPK13 | |
| SCHEMBL2243158 | 0.73 | MAPK13 (0.54) | PTK2MAPK14MAPK12MAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147104-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2012-03-14 | — | — | EP | claimed |