Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Balamapimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 known ✓ | Q02750 | 13/20 | 0.73 |
| ▸ | IGF1R | P08069 | 9/20 | 0.81 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Balamapimod SCHEMBL2965207 | 1.00 | IGF1R (0.81) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2974425 | 0.99 | IGF1R (0.80) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2963305 | 0.95 | IGF1R (0.87) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2968693 | 0.94 | IGF1R (0.78) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2962949 | 0.94 | IGF1R (0.87) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2976171 | 0.94 | IGF1R (0.71) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2975567 | 0.94 | MAP2K1 (0.75) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL14418379 | 0.91 | IGF1R (0.67) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2964257 | 0.91 | IGF1R (0.82) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2966483 | 0.91 | IGF1R (0.66) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250281607-A1 | MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER | TORAY INDUSTRIES, INC. (JP) | 2025-09-11 | — | — | US | disclosed |
| EP-4378478-A1 | MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER | Toray Industries, Inc. (JP) | 2024-06-05 | — | — | EP | disclosed |
| CN-117677398-A | Medicine for treating and/or preventing cancer | 东丽株式会社 | 2024-03-08 | — | — | CN | disclosed |
| WO-2023008462-A1 | MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER | 東レ株式会社 | 2023-02-02 | — | — | WO | disclosed |