Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19971630 | 0.89 | CYP2C19 (0.50) | CYP2C19APLNRCYP1A2ALOX15KDM4E | |
| SCHEMBL10970110 | 0.86 | TSHR (0.43) | CYP2C19APLNRCYP1A2ALOX15KDM4E | |
| SCHEMBL19814952 | 0.86 | TSHR (0.41) | CYP2C19APLNRCYP1A2ALOX15ARG1 | |
| SCHEMBL9715688 | 0.86 | TSHR (0.43) | CYP2C19APLNRCYP1A2ALOX15KDM4E | |
| SCHEMBL1665499 | 0.86 | TSHR (0.43) | CYP2C19APLNRCYP1A2ALOX15KDM4E | |
| SCHEMBL23857824 | 0.82 | KDM4E (0.38) | KDM4EARG1KMT2A | |
| SCHEMBL3346687 | 0.82 | TSHR (0.45) | CYP2C19CYP1A2ALOX15ARG1TSHR | |
| SCHEMBL29585583 | 0.80 | TSHR (0.43) | CYP2C19APLNRCYP1A2ALOX15KDM4E | |
| SCHEMBL19815193 | 0.80 | TSHR (0.42) | CYP2C19APLNRCYP1A2ALOX15KDM4E | |
| SCHEMBL16214734 | 0.79 | TSHR (0.42) | ARG1TSHRGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126825-A1 | AMINOCYCLOBUTANES AS MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |
| EP-4126840-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |
| CN-115362153-A | Aza spiro rings as monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-11-18 | — | — | CN | disclosed |