Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 12/20 | 0.64 |
| ▸ | ABL1 | P00519 | 6/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20519751 | 1.00 | MAP4K1 (0.64) | MAP4K1ABL1JAK2TYK2 | |
| SCHEMBL20519125 | 0.86 | MAP4K1 (0.60) | MAP4K1ABL1JAK2TYK2 | |
| SCHEMBL30107525 | 0.86 | MAP4K1 (0.60) | MAP4K1ABL1JAK2TYK2 | |
| SCHEMBL20519586 | 0.86 | MAP4K1 (0.63) | MAP4K1 | |
| SCHEMBL30107385 | 0.86 | MAP4K1 (0.63) | MAP4K1 | |
| SCHEMBL20519161 | 0.85 | MAP4K1 (0.65) | MAP4K1 | |
| SCHEMBL21334873 | 0.85 | MAP4K1 (0.65) | MAP4K1 | |
| SCHEMBL20517142 | 0.85 | MAP4K1 (0.64) | MAP4K1 | |
| SCHEMBL21334846 | 0.85 | MAP4K1 (0.64) | MAP4K1 | |
| SCHEMBL20524359 | 0.85 | MAP4K1 (0.64) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |